BAIT
SSK22
mitogen-activated protein kinase kinase kinase SSK22, L000002827, YCR073C
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication
GO Process (2)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
STE11
mitogen-activated protein kinase kinase kinase STE11, L000002118, YLR362W
Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade involved in cell wall organization or biogenesis [IGI]
- MAPK cascade involved in osmosensory signaling pathway [IGI, IMP]
- activation of MAPKK activity [IDA, IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein phosphorylation [IDA, IMP]
- pseudohyphal growth [IMP]
- regulation of transposition, RNA-mediated [IMP]
- signal transduction involved in filamentous growth [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway.
Exposure of yeast cells to increases in extracellular osmolarity activates the HOG1 mitogen-activated protein (MAP) kinase cascade, which is composed of three tiers of protein kinases: (i) the SSK2, SSK22, and STE11 MAP kinase kinase kinases (MAPKKKs), (ii) the PBS2 MAPKK, and (iii) the HOG1 MAP kinase. Activation of the MAP kinase cascade is mediated by two upstream mechanisms. The ... [more]
Mol. Cell. Biol. Oct. 01, 1998; 18(10);5788-96 [Pubmed: 9742096]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- SSK2/SSK22/STE11 triple mutants are unable to grow on medium containing sorbitol
- genetic complex
Curated By
- BioGRID