A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast.

Fujita M, Sugiura R, Lu Y, Xu L, Xia Y, Shuntoh H, Kuno T

Calcineurin plays a critical role in Ca(2+) signaling in various cell types. In fission yeast, calcineurin is required for cytokinesis and chloride ion homeostasis. However, most of its physiological functions remain obscure. A genetic screen was performed to identify genes that share an essential function with calcineurin. We screened for mutations that confer sensitivity to the calcineurin inhibitor FK506 and ... [more]

Genetics Jul. 01, 2002; 161(3);971-81 [Pubmed: 12136004]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

text only

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPB1 MYP2	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Fujita M (2002)	Low	-	BioGRID	247577

Curated By

BioGRID

Interaction Summary

PPB1

Gene Ontology Biological Process

Gene Ontology Molecular Function

calcium-dependent protein serine/threonine phosphatase activity [IMP]phosphatase activity [IDA]

Gene Ontology Cellular Component

MYP2