FKBP1A
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- SMAD protein complex assembly [IDA]
- T cell activation [NAS]
- amyloid fibril formation [IDA]
- calcium ion transmembrane transport [NAS]
- chaperone-mediated protein folding [IBA]
- extracellular fibril organization [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [NAS]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of activin receptor signaling pathway [IDA]
- regulation of amyloid precursor protein catabolic process [IGI]
- regulation of immune response [IMP]
- regulation of protein localization [IGI]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
Gene Ontology Cellular Component
SMAD7
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- adherens junction assembly [IMP]
- artery morphogenesis [ISS]
- cellular protein complex localization [IDA]
- cellular response to transforming growth factor beta stimulus [IMP]
- gene expression [TAS]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of cell migration [TAS]
- negative regulation of epithelial to mesenchymal transition [IC, TAS]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IDA, TAS]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-threonine phosphorylation [IDA]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription by competitive promoter binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, TAS]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- pathway-restricted SMAD protein phosphorylation [ISS]
- positive regulation of cell-cell adhesion [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- protein stabilization [IDA]
- regulation of activin receptor signaling pathway [IDA]
- regulation of cardiac muscle contraction [ISS]
- regulation of transforming growth factor beta receptor signaling pathway [IC]
- regulation of ventricular cardiac muscle cell membrane depolarization [IC]
- response to laminar fluid shear stress [IEP]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- activin binding [IPI]
- beta-catenin binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- I-SMAD binding [IPI]
- activin binding [IPI]
- beta-catenin binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.
The cytoplasmic immunophilin FKBP12, a 12 kDa FK506-binding protein, has been shown to act as an inhibitor for transforming growth factor-beta (TGF-beta) signaling. FKBP12 binds to the glycine- and serine-rich motif (GS motif) of the TGF-beta type I receptor, and functions as a secure switch to prevent the leaky signal. Upon stimulation with ligand, FKBP12 is released from the receptor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMAD7 FKBP1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID