BAIT
YPK1
SLI2, serine/threonine protein kinase YPK1, L000002541, YKL126W
Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
GO Process (7)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- eisosome assembly [IGI]
- glycerophospholipid metabolic process [IGI, IMP]
- negative regulation of phospholipid translocation [IMP]
- negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, IMP]
- response to pheromone involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SGK1
SGK, RP1-188K17.1
serum/glucocorticoid regulated kinase 1
GO Process (15)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- ion transmembrane transport [TAS]
- long-term memory [TAS]
- positive regulation of transporter activity [TAS]
- regulation of apoptotic process [TAS]
- regulation of blood pressure [TAS]
- regulation of catalytic activity [TAS]
- regulation of cell growth [TAS]
- regulation of cell migration [TAS]
- regulation of cell proliferation [TAS]
- regulation of gastric acid secretion [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- renal sodium ion absorption [TAS]
- response to stress [TAS]
- sodium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Homo sapiens
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids.
Fatty acids constitute an important energy source for various tissues. The mechanisms that mediate and control uptake of free fatty acids from the circulation, however, are poorly understood. Here we show that efficient fatty-acid uptake by yeast cells requires the protein kinase Ypk1, the orthologue of the human serum- and glucocorticoid-induced kinase Sgk1. ypk1Delta mutant cells fail to grow under ... [more]
J. Cell. Sci. Jul. 01, 2010; 123(0);2218-27 [Pubmed: 20516150]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Curated By
- BioGRID