MIS4
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular response to nitrogen starvation [IMP]
- cohesin localization to chromatin [IMP]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle organization [IMP]
- negative regulation of G0 to G1 transition [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDS5
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [IMP]
- cellular protein localization [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome passenger complex localization to kinetochore [IMP]
- mitotic sister chromatid cohesion [IGI]
- mitotic sister chromatid segregation [IMP]
- protein localization to chromosome, centromeric region [IMP]
- protein localization to kinetochore [IMP]
- regulation of histone H3-T3 phosphorylation [IDA]
- regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MIS4 PDS5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 735429 | |
| PDS5 MIS4 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246718 |
Curated By
- BioGRID