PHO85
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IGI, IMP]
- fungal-type cell wall organization [IGI]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of glycogen biosynthetic process [IMP]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of macroautophagy [IMP]
- protein phosphorylation [IDA]
- regulation of establishment or maintenance of cell polarity [IGI]
- regulation of protein localization [IDA]
- regulation of protein stability [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SFL1
Gene Ontology Biological Process
- gene silencing [IMP]
- negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [IPI]
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Global mapping of the yeast genetic interaction network.
A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO85 SFL1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 81897 |
Curated By
- BioGRID