BAIT

RPN4

SON1, UFD5, stress-regulated transcription factor RPN4, L000001984, YDL020C

Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress

GO Process (7)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

negative regulation of transcription from RNA polymerase II promoter [IMP]

negative regulation of transcription from RNA polymerase II promoter in response to stress [IMP]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI, IMP]

positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]

positive regulation of transcription from RNA polymerase II promoter in response to stress [IEP, IMP]

regulation of DNA repair [IMP]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ICE2

YIL090W

Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells

GO Process (4)

GO Function (0)

GO Component (5)

Gene Ontology Biological Process

cellular zinc ion homeostasis [IMP]

endoplasmic reticulum inheritance [IGI, IMP]

protein targeting to nuclear inner membrane [IMP]

septin ring assembly [IGI, IMP]

Gene Ontology Cellular Component

cortical endoplasmic reticulum [IDA]

endoplasmic reticulum [IDA]

integral component of endoplasmic reticulum membrane [IDA]

integral component of membrane [ISM]

perinuclear endoplasmic reticulum [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

A DNA integrity network in the yeast Saccharomyces cerevisiae.

Pan X, Ye P, Yuan DS, Wang X, Bader JS, Boeke JD

A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]

Cell Mar. 10, 2006; 124(5);1069-81 [Pubmed: 16487579]

Throughput

High Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

confirmed by RSA

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ICE2 RPN4	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.2231	BioGRID	387400
RPN4 ICE2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.2231	BioGRID	364754
ICE2 RPN4	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2219	BioGRID	2132267
RPN4 ICE2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2527	BioGRID	2088826

Curated By

BioGRID

Interaction Summary

RPN4

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

ICE2

Gene Ontology Biological Process

Gene Ontology Cellular Component

Synthetic Growth Defect

Publication

A DNA integrity network in the yeast Saccharomyces cerevisiae.

Throughput

Ontology Terms

Additional Notes

Related interactions

Curated By

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
sequence-specific DNA binding [IDA]