BAIT
GET1
MDM39, YGL020C
Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
VPS15
GRD8, VAC4, VPL19, VPS40, VPT15, ubiquitin-binding serine/threonine protein kinase VPS15, L000002470, L000002924, S000029641, L000002480, YBR097W
Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- inositol lipid-mediated signaling [IMP]
- late endosome to vacuole transport [IMP]
- macroautophagy [IMP]
- peroxisome degradation [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein phosphorylation [IDA]
- protein retention in Golgi apparatus [IMP]
- protein targeting to vacuole [IMP]
- vacuole inheritance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A DNA integrity network in the yeast Saccharomyces cerevisiae.
A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]
Cell Mar. 10, 2006; 124(5);1069-81 [Pubmed: 16487579]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- confirmed by RSA
Curated By
- BioGRID