KIF3A
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- anterior/posterior pattern specification [IMP]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- determination of left/right symmetry [IMP]
- dorsal/ventral neural tube patterning [IGI, IMP]
- dorsal/ventral pattern formation [IMP]
- epidermal stem cell homeostasis [IMP]
- epidermis development [IMP]
- heart development [IMP]
- in utero embryonic development [IGI]
- inner ear receptor stereocilium organization [IMP]
- kidney development [IMP]
- microtubule-based movement [IBA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of receptor-mediated endocytosis [ISO]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axoneme [ISO]
- centrosome [ISO]
- cilium [IDA]
- extracellular vesicular exosome [ISO]
- intraciliary transport particle [IDA]
- kinesin II complex [IDA, ISO]
- microtubule cytoskeleton [ISO]
- neuron projection [IDA]
- photoreceptor connecting cilium [IDA]
- primary cilium [IDA]
- spindle microtubule [ISO]
- synaptic vesicle [ISO]
PPP1R15A
Gene Ontology Biological Process
- endoplasmic reticulum unfolded protein response [IMP]
- negative regulation of phosphoprotein phosphatase activity [ISO]
- negative regulation of protein dephosphorylation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine dephosphorylation [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- protein localization to endoplasmic reticulum [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction between GADD34 and kinesin superfamily, KIF3A.
GADD34 is one of a subset of proteins induced after DNA damage or cell growth arrest. To examine the function of GADD34, we used the yeast two-hybrid system to clone the protein that interacts with the murine GADD34. One cDNA clone was the C-terminal part of KIF3A gene including the tail domain. The interaction between GADD34 and KIF3A was confirmed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP1R15A KIF3A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID