TSC2
Gene Ontology Biological Process
- acute-phase response [IMP]
- cell projection organization [IGI, IMP]
- cellular response to insulin stimulus [ISO]
- establishment of protein localization [IMP]
- glucose import [ISO]
- heart development [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of TOR signaling [IDA, ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein kinase B signaling [IBA, ISO]
- negative regulation of protein kinase activity [ISO]
- neural tube closure [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive chemotaxis [ISO]
- positive regulation of Rab GTPase activity [TAS]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein heterooligomerization [IDA, IMP]
- protein homooligomerization [IDA, IMP]
- protein import into nucleus [ISO]
- protein kinase B signaling [ISO]
- protein localization [ISO]
- protein transport into plasma membrane raft [ISO]
- regulation of cell cycle [IMP]
- regulation of endocytosis [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to hypoxia [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- TSC1-TSC2 complex [IBA, ISO]
- caveola [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- dendrite [IDA]
- growth cone [IDA]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- protein complex [IDA]
YWHAB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cytoplasmic sequestering of protein [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- hippo signaling [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of protein dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of catalytic activity [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
TSC2, or tuberin, is the product of the tuberous sclerosis tumor suppressor gene TSC2 and acts downstream of the phosphatidylinositol 3-kinase-Akt signaling pathway to negatively regulate cellular growth. One mechanism underlying its function is to assemble into a heterodimer with the TSC1 gene product TSC1, or hamartin, resulting in a reduction in phosphorylation, and hence activation, of the ribosomal subunit ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TSC2 YWHAB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID