BAIT
LET-756
CELE_C05D11.4, C05D11.4
let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.
GO Process (4)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
DSH-2
CELE_C27A2.6, C27A2.6
dsh-2 encodes one of three C. elegans Dishevelled (Dsh) homologs; during embryonic development, dsh-2 functions in the Wnt signaling pathway that specifies endoderm and orients the division axis of the EMS blastomere; dsh-2 is also required for many neuronal cell fate specifications and for asymmetric cell division in the early somatic gonad; dsh-2 is additionally required for proper hypodermal morphogenesis during embryonic elongation; DSH-2 is expressed in the embryo from the early stages of embryogenesis through the ~1.5-fold stage; DSH-2 is also expressed in the somatic gonad precursors Z1 and Z4; DSH-2 localizes to the cell cortex.
GO Process (19)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IBA]
- Wnt signaling pathway, regulating spindle positioning [IGI, IMP]
- asymmetric cell division [IMP]
- asymmetric protein localization [IMP]
- body morphogenesis [IMP]
- canonical Wnt signaling pathway [IBA]
- cell fate specification [IGI, IMP]
- digestive tract morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic morphogenesis [IMP]
- endodermal cell fate specification [IGI]
- establishment of mitotic spindle orientation [IGI]
- gonad morphogenesis [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- regulation of signaling [IBA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 1.0 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID