SMA-6
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- body morphogenesis [IMP]
- dauer larval development [IGI]
- defense response to fungus [IMP]
- innate immune response [IMP]
- maintenance of protein location in nucleus [IMP]
- nematode male tail tip morphogenesis [IGI, IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell morphogenesis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYE-1
Gene Ontology Biological Process
- DNA endoreduplication [IMP]
- G1/S transition of mitotic cell cycle [IDA, IMP]
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- germ cell development [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IGI, IMP]
- hermaphrodite genitalia development [IMP]
- mitotic cell cycle arrest [IGI]
- nematode larval development [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of vulval development [IMP]
- post-embryonic development [IMP]
- posttranscriptional regulation of gene expression [IGI, IMP]
- protein phosphorylation [IMP]
- regulation of mitosis [IDA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
Quantitative Score
- 4.7 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CYE-1 SMA-6 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.527 | BioGRID | 2581509 |
Curated By
- BioGRID