BAIT
LET-60
CELE_ZK792.6, lin-34, ZK792.6
let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages.
GO Process (17)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IGI, IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IGI, IMP]
- oogenesis [IGI]
- positive regulation of Rap GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of vulval development [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell projection organization [IGI, IMP]
- reproduction [IGI, IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
PREY
UNC-53
CELE_F45E10.1
Protein UNC-53
GO Process (15)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- axon guidance [IMP]
- backward locomotion [IMP]
- body morphogenesis [IMP]
- cell projection morphogenesis [IMP]
- determination of muscle attachment site [IMP]
- locomotion [IMP]
- mating behavior [IMP]
- mesodermal cell migration [IGI]
- oviposition [IMP]
- positive regulation of axon extension [IMP]
- positive regulation of cell migration [IGI]
- positive regulation of multicellular organism growth [IMP]
- receptor-mediated endocytosis [IMP]
- signal transduction [IPI]
Gene Ontology Molecular Function
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 1.1 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID