SEL-12
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [NAS]
- amyloid precursor protein catabolic process [IBA]
- apical protein localization [IDA]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- cell fate specification [IMP]
- detection of temperature stimulus [IMP]
- membrane protein ectodomain proteolysis [IBA]
- negative regulation of apoptotic process [IBA]
- nervous system development [IMP]
- oviposition [IMP]
- positive regulation of Notch signaling pathway [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- growth cone [IBA]
- integral component of plasma membrane [IBA]
- lysosomal membrane [IBA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nucleus [IBA]
- perinuclear region of cytoplasm [IDA]
GLP-1
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell fate specification [IGI]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic pattern specification [IGI, IMP]
- maintenance of dauer [IGI]
- nematode larval development [IGI, IMP]
- pharyngeal muscle development [IGI, IMP]
- regulation of cell proliferation [IMP]
- regulation of meiosis [IMP]
- reproduction [IMP]
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
Most heritable traits, including disease susceptibility, are affected by interactions between multiple genes. However, we understand little about how genes interact because very few possible genetic interactions have been explored experimentally. We have used RNA interference in Caenorhabditis elegans to systematically test approximately 65,000 pairs of genes for their ability to interact genetically. We identify approximately 350 genetic interactions between ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: sterile (WBPHENOTYPE:0000688)
- phenotype: growth variant (WBPHENOTYPE:0000030)
- phenotype: body morphology variant (WBPHENOTYPE:0000072)
- phenotype: larval lethal (WBPHENOTYPE:0000054)
- phenotype: embryonic lethal (WBPHENOTYPE:0000050)
Additional Notes
- A large-scale genetic interaction analysis was carried out to detect interactions between 37 query mutants and approximately 1,750 target genes compromised by RNA interference (RNAi). Interactions were identified if the phenotype of the combined query-target perturbation was greater than the sum of the two individual perturbations.
- Synthetic
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GLP-1 SEL-12 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 2.75 | BioGRID | 466468 |
Curated By
- BioGRID