BAIT
SEL-12
CELE_F35H12.3, sum-1, F35H12.3
sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.
GO Process (15)
GO Function (2)
GO Component (16)
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [NAS]
- amyloid precursor protein catabolic process [IBA]
- apical protein localization [IDA]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- cell fate specification [IMP]
- detection of temperature stimulus [IMP]
- membrane protein ectodomain proteolysis [IBA]
- negative regulation of apoptotic process [IBA]
- nervous system development [IMP]
- oviposition [IMP]
- positive regulation of Notch signaling pathway [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- growth cone [IBA]
- integral component of plasma membrane [IBA]
- lysosomal membrane [IBA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nucleus [IBA]
- perinuclear region of cytoplasm [IDA]
Caenorhabditis elegans
PREY
SOX-2
CELE_K08A8.2
Protein SOX-2
GO Process (7)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
Most heritable traits, including disease susceptibility, are affected by interactions between multiple genes. However, we understand little about how genes interact because very few possible genetic interactions have been explored experimentally. We have used RNA interference in Caenorhabditis elegans to systematically test approximately 65,000 pairs of genes for their ability to interact genetically. We identify approximately 350 genetic interactions between ... [more]
Nat. Genet. Aug. 01, 2006; 38(8);896-903 [Pubmed: 16845399]
Throughput
- High Throughput
Ontology Terms
- embryonic lethal (WBPHENOTYPE:0000050)
- body morphology variant (WBPHENOTYPE:0000072)
- larval lethal (WBPHENOTYPE:0000054)
Additional Notes
- A large-scale genetic interaction analysis was carried out to detect interactions between 37 query mutants and approximately 1,750 target genes compromised by RNA interference (RNAi). Interactions were identified if the phenotype of the combined query-target perturbation was greater than the sum of the two individual perturbations.
- Synthetic
Curated By
- BioGRID