JAG2
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [NAS, TAS]
- T cell differentiation [IDA]
- auditory receptor cell fate commitment [ISS]
- cell cycle [NAS]
- cell differentiation [IDA]
- regulation of cell migration [NAS]
- regulation of cell proliferation [IDA]
- spermatogenesis [IEP]
- thymic T cell selection [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MIB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.
Recent research has indicated that ligand-dependent activation of the Notch receptor in stromal cells plays a crucial role in the tumorigenesis of multiple myeloma. Ubiquitination of intracellular regions of Notch receptor and its ligands is important for Notch signal transduction. In vitro autoubiquitination analysis using recombinant proteins identified skeletrophin as a novel RING finger-dependent ubiquitin ligase. Skeletrophin bound the intracellular ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID