BAIT

RELA

p65

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

GO Process (41)

GO Function (25)

GO Component (8)

Gene Ontology Biological Process

NIK/NF-kappaB signaling [IBA]

cellular response to hydrogen peroxide [ISO]

cellular response to interleukin-1 [ISO]

cellular response to interleukin-6 [ISO]

cellular response to nicotine [ISO]

cellular response to peptide hormone stimulus [ISO]

cellular response to stress [IBA]

cellular response to tumor necrosis factor [ISO]

cytokine-mediated signaling pathway [ISO]

defense response [IMP]

hair follicle development [IMP]

inflammatory response [ISO]

innate immune response [IBA]

liver development [IMP]

negative regulation of apoptotic process [IDA, ISO]

negative regulation of extrinsic apoptotic signaling pathway [IDA, ISO]

negative regulation of insulin receptor signaling pathway [ISO]

negative regulation of protein catabolic process [IMP]

negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]

negative regulation of transcription, DNA-templated [ISO]

nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]

organ morphogenesis [IMP]

positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]

positive regulation of NF-kappaB transcription factor activity [IDA, ISO]

positive regulation of Schwann cell differentiation [ISO]

positive regulation of cell proliferation [ISO]

positive regulation of chondrocyte differentiation [ISO]

positive regulation of interleukin-12 biosynthetic process [IDA]

positive regulation of miRNA metabolic process [ISO]

positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]

positive regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]

regulation of inflammatory response [IDA]

regulation of transcription from RNA polymerase II promoter [IDA]

response to UV-B [ISO]

response to bacterium [IDA]

response to cytokine [IBA]

response to interleukin-1 [ISO]

response to muramyl dipeptide [IDA]

response to muscle stretch [IDA]

response to organic substance [ISO]

transcription from RNA polymerase II promoter [ISO]

Gene Ontology Molecular Function

DNA binding [IDA, ISO]
NF-kappaB binding [ISO]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
activating transcription factor binding [ISO]
ankyrin repeat binding [IPI]
chromatin binding [IDA, ISO]
enzyme binding [IPI]
identical protein binding [ISO]
phosphate ion binding [ISO]
protein N-terminus binding [ISO]
protein binding [IPI]
protein complex binding [ISO]
protein kinase binding [IPI, ISO]
repressing transcription factor binding [ISO]
sequence-specific DNA binding [IDA, ISO]
sequence-specific DNA binding transcription factor activity [IDA, ISO]
transcription factor binding [ISO]
transcription regulatory region DNA binding [ISO]
ubiquitin protein ligase binding [ISO]

Gene Ontology Cellular Component

I-kappaB/NF-kappaB complex [IBA]

NF-kappaB complex [TAS]

cytoplasm [IDA, ISO]

cytosol [IDA, ISO]

nucleoplasm [IBA]

nucleus [IDA, ISO]

protein complex [ISO]

transcription factor complex [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

EP300

A430090G16, A730011L11, KAT3B, p300, p300 HAT

E1A binding protein p300

GO Process (58)

GO Function (35)

GO Component (7)

Gene Ontology Biological Process

N-terminal peptidyl-lysine acetylation [ISO, ISS]

apoptotic process [ISO, ISS]

cartilage development [NAS]

circadian rhythm [IDA]

heart development [IMP]

histone H2B acetylation [ISO]

histone H3 acetylation [ISO]

histone H4 acetylation [ISO, ISS]

histone acetylation [ISO]

internal peptidyl-lysine acetylation [ISO]

internal protein amino acid acetylation [ISO]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]

lung development [IMP]

negative regulation of cell death [ISO]

negative regulation of cellular metabolic process [ISO]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]

negative regulation of miRNA metabolic process [ISO]

negative regulation of transcription from RNA polymerase II promoter [ISO]

organ morphogenesis [IMP]

positive regulation by host of viral transcription [ISO]

positive regulation of DNA binding [ISO]

positive regulation of axon extension [ISO]

positive regulation of cell death [ISO]

positive regulation of cell growth [ISO]

positive regulation of cell size [ISO]

positive regulation of cellular metabolic process [ISO]

positive regulation of collagen biosynthetic process [ISO]

positive regulation of gene expression [ISO]

positive regulation of glycoprotein biosynthetic process [ISO]

positive regulation of histone acetylation [ISO]

positive regulation of muscle atrophy [ISO]

positive regulation of protein acetylation [ISO]

positive regulation of protein binding [IDA]

positive regulation of protein import into nucleus, translocation [ISO]

positive regulation of protein phosphorylation [ISO]

positive regulation of protein secretion [ISO]

positive regulation of proteolysis [ISO]

positive regulation of sarcomere organization [ISO]

positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO, ISS]

positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]

positive regulation of transcription, DNA-templated [IDA]

positive regulation of translation [ISO]

protein kinase B signaling [ISO]

protein-DNA complex assembly [ISO]

regulation of androgen receptor signaling pathway [ISO]

regulation of angiotensin metabolic process [ISO]

regulation of nucleic acid-templated transcription [IMP]

regulation of transcription, DNA-templated [IDA, ISO, ISS]

regulation of tubulin deacetylation [ISO]

response to calcium ion [ISO]

response to dexamethasone [ISO]

response to drug [ISO]

response to estrogen [ISO]

response to glucose [ISO]

response to hypoxia [ISO, ISS]

skeletal muscle tissue development [IMP]

somitogenesis [IGI]

transcription from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

DNA binding [IDA, ISO, ISS]
NF-kappaB binding [ISO]
RNA polymerase II activating transcription factor binding [IPI, ISO]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
RNA polymerase II core promoter sequence-specific DNA binding [IDA]
RNA polymerase II transcription factor binding [IPI]
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
SMAD binding [ISO]
acetyltransferase activity [IDA, ISO, ISS]
activating transcription factor binding [ISO]
androgen receptor binding [ISO]
antigen binding [ISO]
bHLH transcription factor binding [ISO]
beta-catenin binding [ISO]
chromatin DNA binding [IDA, ISO]
chromatin binding [ISO]
core promoter binding [ISO]
core promoter proximal region DNA binding [ISO]
glucocorticoid receptor binding [ISO]
histone acetyltransferase activity [ISO, ISS]
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [ISO]
mitogen-activated protein kinase binding [ISO]
nuclear hormone receptor binding [ISO]
p53 binding [IPI, ISO]
peroxisome proliferator activated receptor binding [ISO]
pre-mRNA intronic binding [IDA]
protein C-terminus binding [ISO]
protein antigen binding [ISO]
protein binding [IPI]
protein complex binding [ISO]
protein kinase binding [ISO]
sequence-specific DNA binding transcription factor activity [ISO]
transcription coactivator activity [IMP, ISO, ISS]
transcription factor binding [IPI, ISO]
transferase activity, transferring acyl groups [ISO]

Gene Ontology Cellular Component

chromatin [ISO]

cytoplasm [ISO]

histone acetyltransferase complex [IDA]

nucleoplasm [ISO]

nucleus [ISO, ISS]

protein-DNA complex [ISO]

transcription factor complex [IDA]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

An atlas of combinatorial transcriptional regulation in mouse and man.

Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegner J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y

Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]

Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RELA EP300	Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.	Haller D (2003)	Low	-	BioGRID	-
RELA EP300	Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.	Lu Y (2013)	Low	-	BioGRID	-

Curated By

BioGRID