KLF4
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IDA]
- cellular response to laminar fluid shear stress [IMP]
- fat cell differentiation [ISS]
- mesodermal cell fate determination [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [TAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein metabolic process [IGI]
- positive regulation of telomerase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISS]
- positive regulation of transcription, DNA-templated [ISS, NAS]
- post-embryonic hemopoiesis [IMP]
- regulation of cell differentiation [ISS]
- stem cell maintenance [ISS]
- transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
Gene Ontology Cellular Component
HDAC5
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- Notch signaling pathway [TAS]
- cellular response to insulin stimulus [NAS]
- chromatin modification [TAS]
- chromatin organization [TAS]
- chromatin remodeling [TAS]
- chromatin silencing [TAS]
- histone deacetylation [IDA]
- inflammatory response [TAS]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of myotube differentiation [ISS]
- regulation of protein binding [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids.
Phenotypic switching of vascular smooth muscle cells (SMCs), such as increased proliferation, enhanced migration, and downregulation of SMC differentiation marker genes, is known to play a key role in the development of atherosclerosis. However, the factors and mechanisms controlling this process are not fully understood. We recently showed that oxidized phospholipids, including 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), which accumulate in atherosclerotic lesions, are ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC5 KLF4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID