SENP1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic signaling pathway [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- post-translational protein modification [TAS]
- protein desumoylation [IMP]
- protein sumoylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUVBL2
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA, TAS]
- cellular response to UV [IMP]
- cellular response to estradiol stimulus [IMP]
- chromatin organization [TAS]
- chromatin remodeling [IMP]
- establishment of protein localization to chromatin [IMP]
- histone H2A acetylation [IDA]
- histone H4 acetylation [IDA]
- negative regulation of estrogen receptor binding [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein folding [TAS]
- transcriptional activation by promoter-enhancer looping [IMP]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.
Defining the functional modules within transcriptional regulatory factors that govern switching between repression and activation events is a central issue in biology. Recently, we have reported the dynamic role of a beta-catenin-reptin chromatin remodelling complex in regulating a metastasis suppressor gene KAI1 (ref.1), which is capable of inhibiting the progression of tumour metastasis. Here, we identify signalling factors that confer ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RUVBL2 SENP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID