BAIT
DRD1
DADR, DRD1A
dopamine receptor D1
GO Process (22)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IDA]
- activation of adenylate cyclase activity [IDA]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- cellular response to catecholamine stimulus [IDA]
- cerebral cortex GABAergic interneuron migration [ISS]
- dopamine metabolic process [IC]
- mating behavior [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of potassium ion transport [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- prepulse inhibition [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to drug [ISS]
- synapse assembly [ISS]
- transmission of nerve impulse [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HRH3
GPCR97, HH3R
histamine receptor H3
GO Process (2)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.
BACKGROUND AND PURPOSE: Functional interactions between the G protein-coupled dopamine D1 and histamine H3 receptors have been described in the brain. In the present study we investigated the existence of D1-H3 receptor heteromers and their biochemical characteristics. EXPERIMENTAL APPROACH: D1-H3 receptor heteromerization was studied in mammalian transfected cells with Bioluminescence Resonance Energy Transfer and binding assays. Furthermore, signalling through mitogen-activated ... [more]
Br. J. Pharmacol. May. 01, 2009; 157(1);64-75 [Pubmed: 19413572]
Throughput
- Low Throughput
Curated By
- BioGRID