BAIT

MIH1

putative tyrosine protein phosphatase MIH1, L000001111, YMR036C
Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
Kinome Project (Sc)
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ZDS1

CES1, CKM1, NRC1, OSS1, L000002813, YMR273C
Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Zds2p Regulates Swe1p-Dependent Polarized Cell Growth in S. cerevisiae via a Novel Cdc55p Interaction Domain.

Yasutis K, Vignali M, Ryder M, Tameire F, Dighe SA, Fields S, Kozminski KG

Monitoring Editor: David G. Drubin Deletion of the paralogs ZDS1 and ZDS2 in the budding yeast S. cerevisiae causes a mis-regulation of polarized cell growth. Here we show a function for these genes as regulators of the Swe1p (Wee1p) kinase-dependent G2/M checkpoint. We identified a conserved domain in the C-terminus of Zds2p consisting of amino acids 812-913 (hereafter referred to ... [more]

Unknown Oct. 27, 2010; 0(0); [Pubmed: 20980617]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cell cycle progression (APO:0000253)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MIH1 ZDS1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1353BioGRID
2442523

Curated By

  • BioGRID