A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Schizosaccharomyces pombe Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.

Mendoza-Cozatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song WY, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI

Phytochelatins mediate tolerance to heavy metals in plants and some fungi by sequestering phytochelatin-metal complexes into vacuoles. To date, only Schizosaccharomyces pombe Hmt1 has been described as a phytochelatin transporter and attempts to identify orthologous phytochelatin transporters in plants and other organisms have failed. Furthermore, recent data indicate that the hmt1 mutant accumulates significant phytochelatin levels in vacuoles, suggesting that ... [more]

J. Biol. Chem. Oct. 11, 2010; 0(0); [Pubmed: 20937798]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: metal resistance (APO:0000090)

Additional Notes

Cadmium

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CSM1 HMT1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Schwartz MS (2010)	Low	-	BioGRID	435291

Curated By

BioGRID

Interaction Summary

HMT1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity, coupled to transmembrane movement of substances [IMP]glutathione transmembrane transporter activity [IMP]phytochelatin transmembrane transporter ATPase activity [IMP]

Gene Ontology Cellular Component

CSM1