BAIT

TRA1

histone acetyltransferase TRA1, L000003945, YHR099W
Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
Kinome Project (Sc)
GO Process (3)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RPO21

RPB1, RPB220, SUA8, DNA-directed RNA polymerase II core subunit RPO21, B220, L000001744, YDL140C
RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.

Knutson BA, Hahn S

The Tra1 protein is a direct transcription activator target that is essential for coactivator function of both the SAGA and NuA4 histone acetyl transferase (HAT) complexes. The ∼400 kDa S. cerevisiae Tra1 polypeptide and its human counterpart TRRAP contain 67-68 tandem α-helical HEAT and TPR protein repeats that extend from the N-terminus to the conserved yet catalytically inactive PI3K kinase ... [more]

Unknown Dec. 13, 2010; 0(0); [Pubmed: 21149579]

Throughput

  • Low Throughput

Additional Notes

  • ChIP

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TRA1 RPO21
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1425BioGRID
2047694

Curated By

  • BioGRID