SLT2
Gene Ontology Biological Process
- UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [IMP]
- barrier septum assembly [IGI]
- endoplasmic reticulum unfolded protein response [IDA, IMP]
- fungal-type cell wall biogenesis [IGI]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cell size [IMP]
- regulation of fungal-type cell wall organization [IGI, IMP]
- regulation of transcription factor import into nucleus [IMP]
- response to acidic pH [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ROT1
Gene Ontology Biological Process
- 'de novo' protein folding [IMP, IPI]
- budding cell apical bud growth [IGI, IMP]
- endoplasmic reticulum unfolded protein response [IGI]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- fungal-type cell wall biogenesis [IMP]
- protein N-linked glycosylation [IGI, IPI]
- protein O-linked mannosylation [IGI]
- protein folding [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The synthetic genetic interaction spectrum of essential genes.
The nature of synthetic genetic interactions involving essential genes (those required for viability) has not been previously examined in a broad and unbiased manner. We crossed yeast strains carrying promoter-replacement alleles for more than half of all essential yeast genes to a panel of 30 different mutants with defects in diverse cellular processes. The resulting genetic network is biased toward ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- SGA screen
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SLT2 ROT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4271 | BioGRID | 2047210 | |
ROT1 SLT2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 519031 |
Curated By
- BioGRID