BAIT
SEC7
Arf family guanine nucleotide exchange factor SEC7, L000001833, YDR170C
Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
GO Process (3)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SSU72
L000003154, YNL222W
Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
GO Process (11)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- dephosphorylation of RNA polymerase II C-terminal domain [IDA, IMP]
- mRNA 3'-end processing [IMP]
- mRNA cleavage [IMP]
- snoRNA transcription [IMP]
- termination of RNA polymerase II transcription [IMP]
- termination of RNA polymerase II transcription, exosome-dependent [IMP, IPI]
- termination of RNA polymerase II transcription, poly(A)-coupled [IMP, IPI]
- transcription antitermination [IMP]
- transcription elongation from RNA polymerase II promoter [IGI, IMP]
- transcription initiation from RNA polymerase II promoter [IGI, IPI]
- transcriptional start site selection at RNA polymerase II promoter [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The synthetic genetic interaction spectrum of essential genes.
The nature of synthetic genetic interactions involving essential genes (those required for viability) has not been previously examined in a broad and unbiased manner. We crossed yeast strains carrying promoter-replacement alleles for more than half of all essential yeast genes to a panel of 30 different mutants with defects in diverse cellular processes. The resulting genetic network is biased toward ... [more]
Nat. Genet. Oct. 01, 2005; 37(10);1147-52 [Pubmed: 16155567]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- SGA screen
Curated By
- BioGRID