NF1
Gene Ontology Biological Process
- MAPK cascade [IMP]
- Ras protein signal transduction [IGI, IMP]
- Schwann cell development [IMP]
- actin cytoskeleton organization [IGI, IMP]
- adrenal gland development [IMP]
- artery morphogenesis [IMP]
- brain development [IMP]
- camera-type eye morphogenesis [IMP]
- cell communication [IMP]
- cerebral cortex development [IMP]
- cognition [ISO]
- collagen fibril organization [IMP]
- extracellular matrix organization [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- forebrain astrocyte development [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- liver development [IMP]
- metanephros development [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAP kinase activity [IGI, IMP]
- negative regulation of MAPK cascade [IMP, ISO]
- negative regulation of Rac protein signal transduction [IGI]
- negative regulation of Ras protein signal transduction [IGI, IMP]
- negative regulation of angiogenesis [IGI]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell migration [IGI, IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of neuroblast proliferation [IMP]
- negative regulation of neurotransmitter secretion [IGI, IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of protein kinase activity [IGI, IMP]
- negative regulation of transcription factor import into nucleus [IMP]
- neural tube development [IGI]
- osteoblast differentiation [IMP]
- peripheral nervous system development [IMP]
- phosphatidylinositol 3-kinase signaling [IMP]
- pigmentation [IGI, IMP]
- positive regulation of Ras GTPase activity [IGI, IMP, ISO]
- positive regulation of adenylate cyclase activity [IMP]
- positive regulation of apoptotic process [IGI, IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- positive regulation of neuron apoptotic process [IGI, IMP]
- regulation of Ras GTPase activity [ISO]
- regulation of angiogenesis [IMP, ISO]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [IMP]
- regulation of cell proliferation [IGI]
- regulation of cell-matrix adhesion [IMP]
- regulation of glial cell differentiation [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of neuron differentiation [ISO]
- regulation of synaptic transmission, GABAergic [IGI]
- response to hypoxia [IMP]
- skeletal muscle tissue development [IMP]
- smooth muscle tissue development [IMP]
- spinal cord development [IMP]
- sympathetic nervous system development [IMP]
- visual learning [IGI, IMP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMARCA4
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- ATP-dependent chromatin remodeling [ISO]
- DNA methylation on cytosine within a CG sequence [IMP]
- aortic smooth muscle cell differentiation [IMP]
- blastocyst growth [IMP]
- blastocyst hatching [IMP]
- blood vessel development [IMP]
- cell morphogenesis [IMP]
- chromatin remodeling [IMP, ISO]
- definitive erythrocyte differentiation [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic organ morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- extracellular matrix organization [IMP]
- forebrain development [IMP]
- glial cell fate determination [IMP]
- heart development [IMP]
- heart trabecula formation [IGI]
- hindbrain development [IMP]
- histone H3 acetylation [IMP]
- in utero embryonic development [IMP]
- keratinocyte differentiation [IMP]
- lens fiber cell development [IMP]
- liver development [IMP]
- methylation-dependent chromatin silencing [IDA]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nervous system development [IMP]
- neurogenesis [IDA]
- nucleosome assembly [TAS]
- nucleosome disassembly [ISO]
- outflow tract morphogenesis [IMP]
- pharyngeal arch artery morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [IGI]
- positive regulation of Wnt signaling pathway [IMP, ISO]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell migration [IMP]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.
Brg- or hBrm-associated factor (BAF) complexes, a chromatin-remodeling complex family of mammalian cells, facilitate transcriptional activity by remodeling nucleosome structure. Brg1 is the core subunit of Brg-associated factor complexes. In the present study, we investigated the spatial relationship between Brg1 and nuclear factor 1 (NF1/CTF) and RNA polymerase II (RNAP II) upon gene transcriptional activation in vivo by employing immuno-gold ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SMARCA4 NF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID