INP53
Gene Ontology Biological Process
Gene Ontology Molecular Function
YPT1
Gene Ontology Biological Process
- COPII-coated vesicle budding [IMP]
- CVT pathway [IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi vesicle budding [IGI]
- Golgi vesicle docking [IMP]
- SNARE complex disassembly [IMP]
- early endosome to Golgi transport [IMP]
- endocytic recycling [IMP]
- macroautophagy [IMP]
- pre-mRNA catabolic process [IMP]
- protein complex assembly [IDA]
- regulation of endoplasmic reticulum unfolded protein response [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway.
In the budding yeast Saccharomyces cerevisiae, the regulation of phosphatidylinositol 3-phosphate [PtdIns(3)P] is an essential function shared by the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p. The aim of this study was to gain further insight into the mechanisms underlying the toxicity of PtdIns(3)P accumulation in ymr1Delta sjl2Delta sjl3Delta mutant cells. We conducted a genetic screen to ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- genetic complex
- overexpression partially rescues growth in a ymr1/inp52/inp53 triple mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YPT1 INP53 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1273 | BioGRID | 1979229 | |
| YPT1 INP53 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -9.0924 | BioGRID | 900332 |
Curated By
- BioGRID