SNX-1
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- meiotic nuclear division [IMP]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IGI, IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNX-6
Gene Ontology Biological Process
- determination of adult lifespan [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Three Sorting Nexins Drive the Degradation of Apoptotic Cells in Response to PtdIns(3)P Signaling.
Apoptotic cells are swiftly engulfed by phagocytes and degraded inside phagosomes. Phagosome maturation requires phosphatidylinositol 3-phosphate (PtdIns(3)P), yet how PtdIns(3)P triggers phagosome maturation remains largely unknown. Through a genome-wide PtdIns(3)P effector screen in the nematode C. elegans, we identified LST-4/SNX9, SNX-1, SNX-6, three BAR domain-containing sorting nexins, which act in two parallel pathways to drive PtdIns(3)P-mediated degradation of apoptotic cells. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNX-6 SNX-1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SNX-6 SNX-1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.641 | BioGRID | 2579812 | |
| SNX-6 SNX-1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SNX-1 SNX-6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SNX-1 SNX-6 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| SNX-6 SNX-1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| SNX-6 SNX-1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID