BAIT
NFKBIE
IKBE, RP1-302G2.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NCOR2
CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
nuclear receptor corepressor 2
GO Process (9)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.
The NF-kappaB pathway plays a pivotal role in proliferation, differentiation, apoptosis, and immune responses in mammals. The NF-kappaB inhibitor, IkappaB, has classically been characterized for its ability to sequester NF-kappaB transcription factors in the cytoplasm. Nevertheless, a nuclear fraction of IkappaBalpha has consistently been detected and associated with repression of nuclear NF-kappaB. Now we show that IkappaBalpha physically associates with ... [more]
Proc. Natl. Acad. Sci. U.S.A. Nov. 23, 2004; 101(47);16537-42 [Pubmed: 15536134]
Throughput
- Low Throughput
Curated By
- BioGRID