MYO2
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- budding cell apical bud growth [IMP]
- establishment of mitotic spindle orientation [IMP, IPI]
- membrane addition at site of cytokinesis [IEP, IGI, IMP]
- mitochondrion inheritance [IGI, IMP, IPI]
- peroxisome inheritance [IMP, IPI]
- unidimensional cell growth [IMP]
- vacuole inheritance [IGI, IMP, IPI]
- vesicle transport along actin filament [IEP, IMP]
- vesicle-mediated transport [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.
Cell polarity involves transport of specific membranes and macromolecules at the right time to the right place. In budding yeast, secretory vesicles are transported by the myosin-V Myo2p to sites of cell growth. We show that phosphatidylinositol 4-phosphate (PI4P) is present in late secretory compartments and is critical for their association with, and transport by, Myo2p. Further, the trans-Golgi network ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- some myo2 tail mutant alleles show a synthetic growth defect with pik1-139
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MYO2 PIK1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 513089 | |
PIK1 MYO2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 161103 |
Curated By
- BioGRID