BAIT
FGFR2
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
fibroblast growth factor receptor 2
GO Process (96)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- angiogenesis [ISS]
- axonogenesis [ISS]
- bone development [ISS]
- bone mineralization [ISS]
- bone morphogenesis [ISS]
- branch elongation involved in salivary gland morphogenesis [ISS]
- branching involved in labyrinthine layer morphogenesis [ISS]
- branching involved in prostate gland morphogenesis [ISS]
- branching involved in salivary gland morphogenesis [ISS]
- branching morphogenesis of a nerve [ISS]
- bud elongation involved in lung branching [ISS]
- cell fate commitment [ISS]
- cell-cell signaling [ISS]
- digestive tract development [ISS]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [ISS]
- embryonic organ development [ISS]
- embryonic organ morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- epithelial cell proliferation involved in salivary gland morphogenesis [ISS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [ISS]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [ISS]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [ISS]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [ISS]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [ISS]
- gland morphogenesis [ISS]
- hair follicle morphogenesis [ISS]
- in utero embryonic development [ISS]
- innate immune response [TAS]
- inner ear morphogenesis [ISS]
- insulin receptor signaling pathway [TAS]
- lacrimal gland development [ISS]
- lateral sprouting from an epithelium [ISS]
- limb bud formation [ISS]
- lung alveolus development [ISS]
- lung development [ISS]
- lung lobe morphogenesis [ISS]
- lung-associated mesenchyme development [ISS]
- mammary gland bud formation [ISS]
- membranous septum morphogenesis [ISS]
- mesenchymal cell differentiation [ISS]
- mesenchymal cell differentiation involved in lung development [ISS]
- mesenchymal cell proliferation involved in lung development [ISS]
- midbrain development [ISS]
- morphogenesis of embryonic epithelium [ISS]
- multicellular organism growth [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [ISS]
- orbitofrontal cortex development [ISS]
- organ growth [ISS]
- organ morphogenesis [ISS]
- otic vesicle formation [ISS]
- outflow tract septum morphogenesis [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of phospholipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- post-embryonic development [ISS]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [ISS]
- prostate epithelial cord elongation [ISS]
- prostate gland morphogenesis [ISS]
- protein autophosphorylation [IDA]
- pyramidal neuron development [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of branching involved in prostate gland morphogenesis [ISS]
- regulation of cell fate commitment [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [ISS]
- regulation of morphogenesis of a branching structure [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of osteoblast differentiation [TAS]
- regulation of osteoblast proliferation [TAS]
- regulation of smooth muscle cell differentiation [ISS]
- regulation of smoothened signaling pathway [ISS]
- reproductive structure development [ISS]
- skeletal system morphogenesis [TAS]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [ISS]
- ureteric bud development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular zone neuroblast division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STAT3
ADMIO, APRF, HIES
signal transducer and activator of transcription 3 (acute-phase response factor)
GO Process (27)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification.
Fibroblast growth factor receptors (FGFR) are cell surface tyrosine kinases that function in cell proliferation and differentiation. Aberrant FGFR signaling occurs in diverse cancers due to gene amplification, but the associated oncogenic mechanisms are poorly understood. Using a proteomics approach, we identified signal transducers and activators of transcription-3 (STAT3) as a receptor-binding partner that is mediated by Tyr(677) phosphorylation on ... [more]
Cancer Res. Apr. 15, 2010; 70(8);3391-401 [Pubmed: 20388777]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STAT3 FGFR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID