MAPK1
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- ERK1 and ERK2 cascade [IDA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- caveolin-mediated endocytosis [TAS]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [ISS]
- platelet activation [TAS]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [IDA]
- response to stress [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- synaptic transmission [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TOP2A
Gene Ontology Biological Process
- ATP catabolic process [IGI, ISO]
- DNA ligation [ISO]
- DNA topological change [IDA, ISO]
- DNA unwinding involved in DNA replication [IBA]
- apoptotic chromosome condensation [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome condensation [IMP]
- chromosome segregation [IDA, IMP, ISO]
- embryonic cleavage [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- mitotic DNA integrity checkpoint [IBA]
- mitotic recombination [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of viral genome replication [ISO]
- resolution of meiotic recombination intermediates [IBA]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.
The mitogen-activated protein (MAP) kinases, extracellular signal-related kinase 1 (ERK1) and ERK2, regulate cellular responses by mediating extracellular growth signals toward cytoplasmic and nuclear targets. A potential target for ERK is topoisomerase IIalpha, which becomes highly phosphorylated during mitosis and is required for several aspects of nucleic acid metabolism, including chromosome condensation and daughter chromosome separation. In this study, we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID