BAIT
VPS-35
CELE_F59G1.3, F59G1.3
related to yeast Vacuolar Protein Sorting factor
GO Process (5)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
PREY
SNX-1
CELE_C05D9.1, vps-5, C05D9.1
snx-1 encodes a PX and BAR domain-containing protein that is the C. elegans ortholog of the Vps5/SNX1 subunit of the core retromer complex; in C. elegans, SNX-1 functions as a component of the retromer complex that, along with RME-8 and HSP-1, regulates retrograde endosome-to-Golgi transport through control of endosomal clathrin dynamics; SNX-1 binds RME-8 in vitro; SNX-1 is expressed in several different tissues, including the intestine, coelomocytes, and hypodermis; SNX-1 localizes to early endosomes, co-localizing with RME-8.
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- meiotic nuclear division [IMP]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IGI, IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
The cell surface receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Here, we found that the C. elegans intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1. Retromer was recruited to the surfaces of phagosomes containing cell corpses, and its loss of function caused ... [more]
Science Mar. 05, 2010; 327(5970);1261-4 [Pubmed: 20133524]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VPS-35 SNX-1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.891 | BioGRID | 2580688 |
Curated By
- BioGRID