CED-1
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- cellular response to unfolded protein [IDA]
- defense response [IMP]
- defense response to bacterium [IMP]
- engulfment of apoptotic cell [IDA, IMP]
- establishment of protein localization [IDA]
- phagolysosome assembly [IMP]
- programmed cell death [IMP]
- receptor-mediated endocytosis [IPI, ISS]
- recognition of apoptotic cell [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNX-1
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- meiotic nuclear division [IMP]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IGI, IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
The cell surface receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Here, we found that the C. elegans intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1. Retromer was recruited to the surfaces of phagosomes containing cell corpses, and its loss of function caused ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CED-1 SNX-1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID