BAIT
CDC24
CLS4, Rho family guanine nucleotide exchange factor CDC24, L000000262, YAL041W
Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress
GO Process (5)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
RHO1
Rho family GTPase RHO1, L000001630, YPR165W
GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
GO Process (12)
GO Function (1)
GO Component (10)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- actin cytoskeleton reorganization [IGI, IPI]
- budding cell bud growth [IGI, IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of protein kinase C signaling [IDA, IGI, IMP, IPI]
- regulation of cell size [IMP]
- regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [IDA, IMP]
- regulation of exocyst localization [IMP]
- regulation of fungal-type cell wall organization [IMP]
- regulation of protein localization [IMP]
- regulation of vacuole fusion, non-autophagic [IMP]
- small GTPase mediated signal transduction [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Mechanisms for concentrating Rho1 during cytokinesis.
The small GTP-binding protein, Rho1/RhoA plays a central role in cytokinetic actomyosin ring (CAR) assembly and cytokinesis. Concentration of Rho proteins at the division site is a general feature of cytokinesis, yet the mechanisms for recruiting Rho to the division site for cytokinesis remain poorly understood. We find that budding yeast utilizes two mechanisms to concentrate Rho1 at the division ... [more]
Genes Dev. Apr. 01, 2009; 23(7);810-23 [Pubmed: 19339687]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- Rapid cycling Rho1 mutants rescue the lethality of Cdc24/Rom1/Rom2 triple mutants
- genetic complex
Curated By
- BioGRID