BAIT

CDC24

CLS4, Rho family guanine nucleotide exchange factor CDC24, L000000262, YAL041W
Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Mechanisms for concentrating Rho1 during cytokinesis.

Yoshida S, Bartolini S, Pellman D

The small GTP-binding protein, Rho1/RhoA plays a central role in cytokinetic actomyosin ring (CAR) assembly and cytokinesis. Concentration of Rho proteins at the division site is a general feature of cytokinesis, yet the mechanisms for recruiting Rho to the division site for cytokinesis remain poorly understood. We find that budding yeast utilizes two mechanisms to concentrate Rho1 at the division ... [more]

Genes Dev. Apr. 01, 2009; 23(7);810-23 [Pubmed: 19339687]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • Rapid cycling Rho1 mutants rescue the lethality of Cdc24/Rom1/Rom2 triple mutants
  • genetic complex

Curated By

  • BioGRID