BCC2, Bhlhe32, Gsfbcc2, Vitiligo, Wh, bw, mi, vit
microphthalmia-associated transcription factor
GO Process (19)
GO Function (8)
GO Component (2)

Gene Ontology Cellular Component

Mus musculus


AW558298, CBP, CBP/p300, KAT3A, p300/CBP
CREB binding protein
GO Process (11)
GO Function (19)
GO Component (10)
Mus musculus


Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.


CBP/p300 as a co-factor for the Microphthalmia transcription factor.

Sato S, Roberts K, Gambino G, Cook A, Kouzarides T, Goding CR

The Microphthalmia basic-Helix-Loop-Helix-Leucine Zipper (bHLH-LZ) transcription factor (Mi) plays a crucial role in the genesis of melanocytes; mice deficient for a functional (Microphthalmia) gene product lack all pigment cells. We show here that the Mi activation domain resides N-terminal to the DNA-binding domain and that as little as 18 amino acids are sufficient to mediate transcription activation. The minimal activation ... [more]

Oncogene Jun. 26, 1997; 14(25);3083-92 [Pubmed: 9223672]


  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Curated By

  • BioGRID