SIT4
Gene Ontology Biological Process
- DNA repair [IMP]
- G1/S transition of mitotic cell cycle [IGI]
- TOR signaling [IMP]
- actin cytoskeleton organization [IMP]
- cellular response to oxidative stress [IMP]
- dephosphorylation [IMP]
- fungal-type cell wall organization [IMP]
- intracellular signal transduction [IMP]
- replicative cell aging [IMP]
- tRNA wobble uridine modification [IMP]
Gene Ontology Molecular Function
SIS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions.
The yeast gene VHS3 (YOR054c) has been recently identified as a multicopy suppressor of the G(1)/S cell cycle blockade of a conditional sit4 and hal3 mutant. Vhs3 is structurally related to Hal3, a negative regulatory subunit of the Ser/Thr protein phosphatase Ppz1 important for cell integrity, salt tolerance, and cell cycle control. Phenotypic analyses using vhs3 mutants and overexpressing strains ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle passage through start (APO:0000256)
- phenotype: budding index (APO:0000089)
- phenotype: growth in exponential phase (APO:0000310)
Additional Notes
- Effect on budding index mentioned but not shown.
- Overexpression of VHS3 or HAL3 improved the slow growth phenotype of a sit4 deletion mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SIT4 SIS2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 591225 | |
SIT4 SIS2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155451 | |
SIT4 SIS2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158819 | |
SIS2 SIT4 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158127 |
Curated By
- BioGRID