PPH1, type 2A-related serine/threonine-protein phosphatase SIT4, L000001901, YDL047W
Type 2A-related serine-threonine phosphatase; functions in the G1/S transition of the mitotic cycle; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6
Saccharomyces cerevisiae (S288c)


L000004347, YOL028C
Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.


Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.

Munoz I, Simon E, Casals N, Clotet J, Arino J

Inactivation of HAL3 in the absence of SIT4 function leads to cell cycle arrest at the G(1)-S transition. To identify genes potentially involved in the control of this phase of the cell cycle, a screening for multicopy suppressors of a conditional sit4 hal3 mutant (strain JC002) has been developed. The screening yielded several genes known to perform key roles in ... [more]

Yeast Jan. 30, 2003; 20(2);157-69 [Pubmed: 12518319]


  • Low Throughput

Ontology Terms

  • phenotype: cell cycle progression through the g1/s phase transition (APO:0000269)

Additional Notes

  • genetic complex
  • overexpression rescues the G1-S cell cycle blockage seen in a Sis2/Sit4 mutant

Curated By

  • BioGRID