MOB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TPK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection.
In Saccharomyces cerevisiae, Ras proteins connect nutrient availability to cell growth through regulation of protein kinase A (PKA) activity. Ras proteins also have PKA-independent functions in mitosis and actin repolarization. We have found that mutations in MOB2 or CBK1 confer a slow-growth phenotype in a ras2Delta background. The slow-growth phenotype of mob2Delta ras2Delta cells results from a G1 delay that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: budding pattern (APO:0000200)
- phenotype: cell cycle progression through the g1/s phase transition (APO:0000269)
Additional Notes
- TPK1 overexpression partially restores entry into S-phase for a ras2 mob2 double mutant.
- TPK1 overexpression partially suppresses the bud site selection phenotype of a ras2 mob2 double mutant.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MOB2 TPK1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155796 |
Curated By
- BioGRID