LSM4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MCA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Yeast caspase 1 links messenger RNA stability to apoptosis in yeast.
During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial function and YCA1, which encodes a budding yeast metacaspase, are necessary for ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: oxidative stress resistance (APO:0000083)
- phenotype: acid ph resistance (APO:0000201)
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: viability (APO:0000111)
- phenotype: utilization of carbon source (APO:0000098)
Additional Notes
- Halo test with H2O2
- LSM4 was deleted and replaced with a truncated form of K. lactis LSM4
- Partial rescue on acetic acid
- Partial rescue on glycerol
- WT rescue on caffeine
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
LSM4 MCA1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 227825 |
Curated By
- BioGRID