BAIT
CDC55
TMR4, protein phosphatase 2A regulatory subunit CDC55, L000000282, S000029602, L000003191, YGL190C
Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55
GO Process (7)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- negative regulation of exit from mitosis [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription by transcription factor localization [IMP]
- protein dephosphorylation [IDA, IMP]
- regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SLK19
L000004340, YOR195W
Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
GO Process (5)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae.
In budding yeast Saccharomyces cerevisiae, Cdc5 kinase is a component of mitotic exit network (MEN), which inactivates cyclin-dependent kinase (CDK) after chromosome segregation. cdc5-1 mutants arrest at telophase at the nonpermissive temperature due to the failure of CDK inactivation. To identify more negative regulators of MEN, we carried out a genetic screen for genes that are toxic to cdc5-1 mutants ... [more]
Mol. Biol. Cell Jan. 01, 2006; 17(1);80-9 [Pubmed: 16079183]
Throughput
- Low Throughput
Ontology Terms
- phenotype: budding index (APO:0000089)
Curated By
- BioGRID