BAIT

RLM1

L000003028, YPL089C
MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)
PREY

GSC2

FKS2, 1,3-beta-glucan synthase GSC2, L000000716, L000000733, YGR032W
Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication
GO Process (2)
GO Function (1)
GO Component (4)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin.

Zhao C, Jung US, Garrett-Engele P, Roe T, Cyert MS, Levin DE

FKS1 and FKS2 are alternative subunits of the glucan synthase complex, which is responsible for synthesizing 1,3-beta-glucan chains, the major structural polymer of the Saccharomyces cerevisiae cell wall. Expression of FKS1 predominates during growth under optimal conditions. In contrast, FKS2 expression is induced by mating pheromone, high extracellular [Ca2+], growth on poor carbon sources, or in an fks1 mutant. Induction ... [more]

Mol. Cell. Biol. Feb. 01, 1998; 18(2);1013-22 [Pubmed: 9447998]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • genetic complex
  • overexpression of the hit gene rescues viability in an fks1/rlm1 double mutant

Curated By

  • BioGRID