BAIT
STE11
mitogen-activated protein kinase kinase kinase STE11, L000002118, YLR362W
Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade involved in cell wall organization or biogenesis [IGI]
- MAPK cascade involved in osmosensory signaling pathway [IGI, IMP]
- activation of MAPKK activity [IDA, IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein phosphorylation [IDA, IMP]
- pseudohyphal growth [IMP]
- regulation of transposition, RNA-mediated [IMP]
- signal transduction involved in filamentous growth [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
MCM1
FUN80, transcription factor MCM1, L000001037, YMR043W
Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia
GO Process (9)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of mating-type specific transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of mating-type specific transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of mating type switching [IMP]
Gene Ontology Molecular Function- DNA replication origin binding [IDA]
- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending [IDA, IMP]
- RNA polymerase II repressing transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IPI]
- DNA replication origin binding [IDA]
- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending [IDA, IMP]
- RNA polymerase II repressing transcription factor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IPI]
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.
In Saccharomyces cerevisiae, mating pheromones activate two MAP kinases (MAPKs), Fus3p and Kss1p, to induce G1 arrest prior to mating. Fus3p is known to promote G1 arrest by activating Far1p, which inhibits three Clnp/Cdc28p kinases. To analyze the contribution of Fus3p and Kss1p to G1 arrest that is independent of Far1p, we constructed far1 CLN strains that undergo G1 arrest ... [more]
Genetics Mar. 01, 1999; 151(3);989-1004 [Pubmed: 10049917]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression in g1 phase (APO:0000255)
Additional Notes
- genetic complex
- overexpression of MCM1 blocks the G1 arrest seen in a Ste11/Far1/Kss1, Ste11/Far1/Hog1 or Ste11/Far1/Mpk1 triple mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STE11 MCM1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 520695 |
Curated By
- BioGRID