BAIT

KSS1

mitogen-activated serine/threonine-protein kinase KSS1, L000000922, YGR040W
Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
Saccharomyces cerevisiae (S288c)
PREY

MCM1

FUN80, transcription factor MCM1, L000001037, YMR043W
Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia
GO Process (9)
GO Function (9)
GO Component (3)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.

Cherkasova V, Lyons DM, Elion EA

In Saccharomyces cerevisiae, mating pheromones activate two MAP kinases (MAPKs), Fus3p and Kss1p, to induce G1 arrest prior to mating. Fus3p is known to promote G1 arrest by activating Far1p, which inhibits three Clnp/Cdc28p kinases. To analyze the contribution of Fus3p and Kss1p to G1 arrest that is independent of Far1p, we constructed far1 CLN strains that undergo G1 arrest ... [more]

Genetics Mar. 01, 1999; 151(3);989-1004 [Pubmed: 10049917]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cell cycle progression in g1 phase (APO:0000255)

Additional Notes

  • genetic complex
  • overexpression of MCM1 blocks the G1 arrest seen in a Ste11/Far1/Kss1, Ste11/Far1/Hog1 or Ste11/Far1/Mpk1 triple mutant

Curated By

  • BioGRID