BAIT

AXIN2

Axi1, Axil, Conductin, RP23-202G21.3
axin2
GO Process (30)
GO Function (8)
GO Component (13)
Mus musculus
PREY

LEF1

3000002B05, AI451430, Lef-1
lymphoid enhancer binding factor 1
GO Process (74)
GO Function (22)
GO Component (4)

Gene Ontology Biological Process

Mus musculus

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

Behrens J, Jerchow BA, Wuertele M, Grimm J, Asbrand C, Wirtz R, Kuehl M, Wedlich D, Birchmeier W

Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also ... [more]

Science Apr. 24, 1998; 280(5363);596-9 [Pubmed: 9554852]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: abnormal protein level (MP:0008469)

Additional Notes

  • coexpression of Lef-1 blocks the degradation of beta catenin seen when Axin2 is transfected into cells

Curated By

  • BioGRID