BAIT
AXIN2
Axi1, Axil, Conductin, RP23-202G21.3
axin2
GO Process (30)
GO Function (8)
GO Component (13)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IBA]
- bone mineralization [IMP]
- cell death [IBA, ISO]
- cell proliferation [IMP]
- cellular protein localization [ISO]
- cellular response to organic cyclic compound [IBA]
- chondrocyte differentiation involved in endochondral bone morphogenesis [IMP]
- dorsal/ventral axis specification [IBA]
- intramembranous ossification [IMP]
- mRNA stabilization [ISO]
- maintenance of DNA repeat elements [ISO]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- negative regulation of canonical Wnt signaling pathway [IBA, ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of osteoblast differentiation [IMP]
- odontogenesis [ISO]
- positive regulation of GTPase activity [IBA]
- positive regulation of cell death [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of Wnt signaling pathway [IDA]
- regulation of catenin import into nucleus [IBA]
- regulation of centromeric sister chromatid cohesion [IMP, ISO]
- regulation of chondrocyte development [IMP]
- regulation of mismatch repair [ISO]
- regulation of transcription, DNA-templated [IBA]
- secondary heart field specification [IGI]
- somitogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- beta-catenin destruction complex [IBA]
- cell cortex [IBA]
- centrosome [IDA, ISO]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [IBA]
- cytoplasmic microtubule [IBA]
- microtubule cytoskeleton [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IBA]
- postsynaptic density [IBA]
- protein complex [ISO]
Mus musculus
PREY
LEF1
3000002B05, AI451430, Lef-1
lymphoid enhancer binding factor 1
GO Process (74)
GO Function (22)
GO Component (4)
Gene Ontology Biological Process
- B cell proliferation [IMP]
- BMP signaling pathway [IDA]
- T cell receptor V(D)J recombination [IGI]
- T-helper 1 cell differentiation [IDA]
- Wnt signaling pathway [IDA, IGI, IMP, ISO]
- alpha-beta T cell differentiation [IGI]
- anatomical structure regression [IMP]
- apoptotic process involved in morphogenesis [IMP]
- apoptotic process involved in patterning of blood vessels [IMP]
- canonical Wnt signaling pathway [IBA, ISO]
- cell chemotaxis [ISO]
- cell development [IGI]
- cellular response to cytokine stimulus [ISO]
- cellular response to interleukin-4 [ISO]
- chorio-allantoic fusion [IGI]
- dentate gyrus development [IMP]
- embryonic limb morphogenesis [IGI]
- epithelial to mesenchymal transition [IMP]
- eye pigmentation [IBA]
- face morphogenesis [IGI]
- forebrain neuroblast division [IGI]
- forebrain neuron differentiation [IBA]
- forebrain radial glial cell differentiation [IGI]
- formation of radial glial scaffolds [IGI]
- hippocampus development [IMP]
- histone H3 acetylation [ISO]
- histone H4 acetylation [ISO]
- hypothalamus development [IBA]
- mammary gland development [IMP]
- muscle fiber development [IBA]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of apoptotic process in bone marrow [IBA, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IBA, ISO]
- negative regulation of estrogen receptor binding [ISO]
- negative regulation of interleukin-13 production [IBA, ISO]
- negative regulation of interleukin-4 production [IBA, ISO]
- negative regulation of interleukin-5 production [IBA, ISO]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neural crest cell migration [IBA]
- neutrophil differentiation [IBA, ISO]
- odontoblast differentiation [IBA, ISO]
- odontogenesis of dentin-containing tooth [IGI, IMP]
- osteoblast differentiation [IBA]
- palate development [IMP]
- paraxial mesoderm formation [IGI]
- patterning of blood vessels [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of cell cycle process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation in bone marrow [IBA, ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- regulation of Wnt signaling pathway [IGI]
- regulation of cell-cell adhesion [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- sensory perception of taste [IMP]
- somitogenesis [IGI, IMP]
- sprouting angiogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tongue development [IMP]
- trachea gland development [IMP]
- transcription from RNA polymerase II promoter [IGI, ISO]
- vasculature development [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IGI]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IBA, ISO]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- enhancer binding [IBA, ISO]
- estrogen receptor activity [ISO]
- estrogen receptor binding [IBA, ISO]
- gamma-catenin binding [IBA, ISO]
- histone binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IBA, IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IGI]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IBA, ISO]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- enhancer binding [IBA, ISO]
- estrogen receptor activity [ISO]
- estrogen receptor binding [IBA, ISO]
- gamma-catenin binding [IBA, ISO]
- histone binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IBA, IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also ... [more]
Science Apr. 24, 1998; 280(5363);596-9 [Pubmed: 9554852]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- coexpression of Lef-1 blocks the degradation of beta catenin seen when Axin2 is transfected into cells
Curated By
- BioGRID