BAIT
STE20
mitogen-activated protein kinase kinase kinase kinase STE20, L000002123, YHL007C
Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family
GO Process (17)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- activation of MAPKKK activity [IDA]
- bipolar cellular bud site selection [IGI, IMP]
- budding cell apical bud growth [IGI, IMP]
- cellular bud site selection [IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of gene expression [IGI, IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI, IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of apoptotic process [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- signal transduction involved in filamentous growth [IMP]
- sterol import [IMP]
- stress granule assembly [IGI, IMP]
- vacuole inheritance [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
CKB1
casein kinase 2 regulatory subunit CKB1, L000002856, YGL019W
Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.
Protein kinases are key regulators of cellular processes. In spite of considerable effort, a full understanding of the pathways they participate in remains elusive. We globally investigated the proteins that interact with the majority of yeast protein kinases using protein microarrays. Eighty-five kinases were purified and used to probe yeast proteome microarrays. One-thousand-twenty-three interactions were identified, and the vast majority ... [more]
Genes Dev. Apr. 01, 2011; 25(7);767-78 [Pubmed: 21460040]
Throughput
- High Throughput
Additional Notes
- High Throughput: Proteome microarrays were used to identify proteins that interact with protein kinases.
Curated By
- BioGRID