KAT5
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- androgen receptor signaling pathway [NAS]
- cellular response to estradiol stimulus [IDA]
- chromatin organization [TAS]
- double-strand break repair [IMP]
- histone acetylation [IDA]
- negative regulation of interleukin-2 production [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- response to ionizing radiation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KLF4
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IDA]
- cellular response to laminar fluid shear stress [IMP]
- fat cell differentiation [ISS]
- mesodermal cell fate determination [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [TAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein metabolic process [IGI]
- positive regulation of telomerase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISS]
- positive regulation of transcription, DNA-templated [ISS, NAS]
- post-embryonic hemopoiesis [IMP]
- regulation of cell differentiation [ISS]
- stem cell maintenance [ISS]
- transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity.
KLF4 is a transcription factor that is highly expressed in the gastrointestinal tract. Previously we have demonstrated that KLF4 represses HDC promoter activity in a gastric cell line through both an upstream Sp1 binding GC box and downstream gastrin responsive elements. However, the mechanism by which KLF4 inhibits HDC promoter is not well defined. In the current study, by using ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KLF4 KAT5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KAT5 KLF4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KLF4 KAT5 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID