LRP6
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IMP]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- Wnt signaling pathway involved in somitogenesis [IBA]
- anterior/posterior pattern specification [IBA]
- axis elongation involved in somitogenesis [IBA]
- bone morphogenesis [IBA]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural crest cell differentiation [IC]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IC]
- cellular response to cholesterol [IMP]
- cerebellum morphogenesis [IBA]
- cerebral cortex development [IBA]
- convergent extension [IBA]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic pattern specification [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- external genitalia morphogenesis [IBA]
- face morphogenesis [IBA]
- gastrulation with mouth forming second [IBA]
- midbrain development [IBA]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- neural crest cell differentiation [IDA]
- neural crest formation [IDA]
- neural tube closure [IBA]
- odontogenesis of dentin-containing tooth [IBA]
- palate development [IBA]
- pericardium morphogenesis [IBA]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- primitive streak formation [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IBA]
- regulation of fat cell differentiation [IBA]
- regulation of ossification [IBA]
- synaptic transmission [IBA]
- thalamus development [IBA]
- toxin transport [IMP]
- trachea cartilage morphogenesis [IBA]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
NPC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Mutation in the EGFP domain of LDL receptor-related protein 6 (LRP6(R611C)) is associated with hypercholesterolemia and early-onset atherosclerosis, but the mechanism by which it causes disease is not known. Cholesterol uptake was examined in cells from LRP6(+/-) mice and LRP6(R611C) mutation carriers. Splenic B cells of LRP6(+/-) mice have significantly lower LRP6 expression and low-density lipoprotein (LDL) uptake than those ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID