BAIT

NTMT1

AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NTM1A, RP11-483H20.8
N-terminal Xaa-Pro-Lys N-methyltransferase 1
GO Process (5)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RCC1

CHC1, RCC1-I, SNHG3-RCC1, RP4-669K10.2
regulator of chromosome condensation 1
Cell Cycle - Mitotic Spindle Assembly Project
Homo sapiens

Biochemical Activity (Methylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG

The post-translational methylation of alpha-amino groups was first discovered over 30 years ago on the bacterial ribosomal proteins L16 and L33 (refs 1, 2), but almost nothing is known about the function or enzymology of this modification. Several other bacterial and eukaryotic proteins have since been shown to be alpha-N-methylated. However, the Ran guanine nucleotide-exchange factor, RCC1, is the only ... [more]

Nature Aug. 26, 2010; 466(7310);1125-8 [Pubmed: 20668449]

Throughput

  • Low Throughput

Curated By

  • BioGRID