Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

An integrated approach to characterize genetic interaction networks in yeast metabolism.

Szappanos B, Kovacs K, Szamecz B, Honti F, Costanzo M, Baryshnikova A, Gelius-Dietrich G, Lercher MJ, Jelasity M, Myers CL, Andrews BJ, Boone C, Oliver SG, Pal C, Papp B

Although experimental and theoretical efforts have been applied to globally map genetic interactions, we still do not understand how gene-gene interactions arise from the operation of biomolecular networks. To bridge the gap between empirical and computational studies, we i, quantitatively measured genetic interactions between âˆ¼185,000 metabolic gene pairs in Saccharomyces cerevisiae, ii, superposed the data on a detailed systems biology ... [more]

Unknown May. 29, 2011; 0(0); [Pubmed: 21623372]

Quantitative Score

-0.1006 [SGA Score]

Throughput

High Throughput

Ontology Terms

phenotype: colony size (APO:0000063)

Additional Notes

cut-off value: interaction score > .08 and < -.08

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
GAS2 GAS4	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ragni E (2007)	Low	-	BioGRID	239237

Curated By

BioGRID

Interaction Summary

GAS2

Gene Ontology Biological Process

Gene Ontology Molecular Function

1,3-beta-glucanosyltransferase activity [IDA, ISS]

Gene Ontology Cellular Component

GAS4